Abstract
Disclosed herein is a novel, metal-free synthesis of γ-lactams through the radical-mediated nitration-aminocarbonylation of unactivated olefins. The reaction is initiated by a nitro radical generated from the homolysis of tert-butyl nitrite. The intramolecular cyanamide serves as the aminocarbonylating reagent. This protocol offers an environment-benign method to produce the synthetically valuable nitromethyl substituted γ-lactams.
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