Abstract

The present work describes intramolecular cyclization of 4-(hydroxyamino)-2-oxo-6-aryl-N-(substituted)-2H-pyran-3-carboxamides (1a-e) under the basic condition to yield fused pyranoisoxazoles (2a-e). The X-ray structural studies delineate a network of non-covalent forces that provided a molecular packing motif to generate a reproducible stacking pattern towards column scaffold formation in the pyranoisoxazole crystal system.

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