Abstract
Previous studies have shown that transplantation of fetal rat small bowel into the greater omentum of adult recipient animals can be successfully carried out. However, the surface area of the omentum limits the length of implantable fetal small bowel. Furthermore, clinical experience has shown that due to adhesions, the greater omentum is no longer suitable as an implantation site after multiple laparotomies, which often precede a short-bowel syndrome. We wanted to examine whether recipient mesentery is a further possible site of fetal gut implantation. Four weeks after transplantation of the fetal graft into the mesentery of adult rats, mature intestine was found in 80% of the animals. Macroscopically, the developed transplants looked like “bowel duplications"; light-microscopic examinations documented their morphologic integrity.
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