Intralipid treatment: Is it only the tip of an iceberg? A new suggestion: Bone cement implantation syndrome (BCIS)

Joseph Eldor,Vladimir Kotlovker

doi:10.7243/2049-9752-1-12

Abstract

Abstract On 1998 it was first showed that intravenous intralipid could prevent or improve resuscitation from cardiovascular collapse by severe bupivacaine overdose in rats. Since then published examples now include toxicities related to

Highlights

Intralipid® 10% (10% i.v fat emulsion) (a 10% intravenous fat emulsion) is a sterile, non-pyrogenic fat emulsion prepared for intravenous administration as a source of calories and essential fatty acids. it is made up of 10% soybean oil, 1.2% egg yolk phospholipids, 2.25% glycerin, and water for injection. in addition, sodium hydroxide has been added to adjust the ph so that the final product ph is 8. ph range is 6 to 8.9
Purified egg phosphatides are a mixture of naturally occurring phospholipids which are isolated from the egg yolk
Weinberg et al, [1] first showed in 1998 that an infusion of a soybean oil emulsion normally used as a total parenteral nutrition solution could prevent or improve resuscitation from cardiovascular collapse caused by severe bupivacaine overdose in the intact, anesthetized rat

Summary

Introduction

Intralipid® 10% (10% i.v fat emulsion) (a 10% intravenous fat emulsion) is a sterile, non-pyrogenic fat emulsion prepared for intravenous administration as a source of calories and essential fatty acids. it is made up of 10% soybean oil, 1.2% egg yolk phospholipids, 2.25% glycerin, and water for injection. in addition, sodium hydroxide has been added to adjust the ph so that the final product ph is 8. ph range is 6 to 8.9. Weinberg et al, [1] first showed in 1998 that an infusion of a soybean oil emulsion normally used as a total parenteral nutrition solution could prevent (by pretreatment) or improve resuscitation from cardiovascular collapse caused by severe bupivacaine overdose in the intact, anesthetized rat. The effectiveness of lipid emulsion infusion in reversing LAST has been confirmed in other laboratories and by systematic analysis [4] in the clinical setting as well.

Results

Conclusion