Intralesional steroids augment the effect of endoscopic dilation in corrosive-induced esophageal strictures

Abstract

functional dyspepsia (5 men and 15 women, ages 20 to 55 years) with dysmotility-like dyspepsia symptoms (Rome criteria). Subjects consumed a light breakfast (4 oz. of apple juice and toast with butter or margarine) 2-3 hours before the EGG test. In the laboratory, subjects ingested water until feeling full (water load test). EGGs were recorded for 15 min. preand 30 min. post-water ingestion. The percentages of EGG total power in the bradygastria (0-2.25 cycles per min., cpm), normal (2.25-3.75 cpm), tachygastria 3.75-10 cpm) and duodenal (10.0-15 cpm) ranges were calculated. Data from control subjects were used to establish normative EGG data (mean +_ 1 SD). EGG results from each of the 20 patients were compared with the normative EGG data to determine whether a given patient's EGG fell within (normal result) or outside (abnormal result) the normal range. Results: Abnormal EGG responses to the water load test were found in 11 of 20 patients (55%). The Normal-EGG and Abnormal-EGG patient groups drank similar volumes of water (Abnormal-EGG = 395 +-41 ml, Normal-EGG = 385+-41 mi). The Abnormal-EGG group showed an increase in bradygastria and decrease in 3 cpm activity in response to the water load that was not observed the Normal-EGG group (F[3/54]=4.6, p <0.05 and F[3/54]=3.6, p < 0.05, respectively). In addition, the Abnormal-EGG group showed more tachygastria throughout the recording period compared to the Normal-EGG group (F[1/18]=5.8, p < 0.05). Conclusions: 1) In controls and patients the water load test provides a standard stimulus for evaluating gastric myoelectrical activity responses with the EGG; 2) Patients with dysmotilitylike dyspepsia may be defined in terms of normal vs. abnormal EGG responses, responses that provide an objective measure for definitions of functional dyspepsia and treatment protocols.