Intralesional Injection of Adalimumab for Anal Stricture in Pediatric Crohn’s Disease: A Therapeutic Option?

Abstract

The symptomatic stricturing Crohn’s disease is incapacitating and usually associated with therapeutic failures requiring surgery. We herein described a 13-year-old Caucasian male evaluated for a second opinion in the pediatric gastroenterology clinic for an anal Crohn’s stricture. The patient underwent serial anal dilations followed by intralesional injection of the adalimumab. In spite of a wide range of therapeutic options for the management of Crohn’s disease, the effectiveness of serial adalimumab intralesional injection in anal strictures to maintain anal patency has not been reported. We described the use of intralesional adalimumab to maintain the patency of the anal canal.