Abstract
Objectives: The goal of this study is to determine if the use of Cidofovir injected locally reduces the number of debulking procedures on pediatric patients with recurrente respiratory papillomatosis. Methods: We injected 37.5 mg of Cidofovir intralesionaly in each patient with a laryngeal gauze 27, each 3 weeks for a total of 5 times on each patients.In each patients Hematic count, Hepatic enzymes, and BUN in each patient was done 1 week after and 1 week before each injection. Results: We included 7 patients in a 18-month period, 6 of the 7 patients have not needed a debulking procedure in the last 10 months, the obstruction and voice improved, 1 of the patients needed 3 more injections, and has not needed another debulking procedure in the last 3 months; none of the patients had any laboratory alteration. Conclusion: Cidofovir is a drug effective in the treatment of recurrent respiratory papillomatosis, probably reducing the papilomatosis activity in the laringeal tissue.
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