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Abstract
To the Editor: The standard treatment for squamous cell carcinomas (SCCs) is wide local excision or Mohs micrographic surgery. Excision of SCCs in difficult areas, such as the lower extremity, can be challenging and associated with increased complications.1 Intralesional 5-fluorouracil (IL5-FU) is a minimally invasive therapeutic option that may benefit select patients for whom surgical excision is not desired or feasible. Most studies to date have been limited to small studies, case series, and recent case reports.
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