Intrahippocampal transplantation of ES cell-derived neural precursor cells into a chronic epilepsy model - functional analysies

Abstract

Despite the potential of embryonic stem (ES) cell-based reconstructive approaches, very little is known about the functional properties of these cells after in vivo transplantation into the adult central nervous system, especially into a pathologically altered environment. Here, we have analyzed the functional integration of ES cell-derived neurons (ESNs) into an adult rat model of chronic epilepsy.