Intrahippocampal injection of dopamine D1 receptor antagonist SCH23390 interferes with locomotion and learning of active place avoidance, a spatial cognition task

Abstract

Event Abstract Back to Event Intrahippocampal injection of dopamine D1 receptor antagonist SCH23390 interferes with locomotion and learning of active place avoidance, a spatial cognition task Tomas Petrasek1*, Karel Vales1 and Ales Stuchlik1 1 ASCR, Institute of Physiology, Czechia Neurophysiology of spatial cognition in laboratory rodents is a current topic in behavioral neuroscience. Neurotransmitter substrates are usually studied utilizing the application of specific receptor agonists and antagonists. Contrary to systemic administration, local microinfusions of such drugs have the advantage of selectively targeting the specific brain regions. The present study was aimed at evaluating the role of hippocampal D1 dopamine receptors in performance of Long-Evans rats in an active place avoidance task. This spatial task has been demonstrated to involve cognitive coordination and to be highly dependent upon hippocampal integrity. Adult male rats were implanted with guide cannulae targeted above the dorsal hippocampus. After recovery, the animals were microinfused with a D1 receptor antagonist SCH23390 (at doses 0.5ug, 2ug and 5ug) bilaterally through thin cannula inserts and 30 minutes later tested in the active place avoidance task. Locomotor activity in place avoidance was dose-dependently decreased by SCH23390, whilst the spatial performance (measured by number of entrances into prohibited zone and latency to the first entrance) was found to decrease without a dose-response relationship. These results suggest that dopamine D1 receptors in the hippocampus participate in regulation of locomotion and establishment of a memory trace during initial acquisition in the place avoidance task. This study was supported by GACR grants 309/07/0341, 309/09/0286, IGA MZ CR NR/9178, and MSMT CR 1M0517 and LC554. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Petrasek T, Vales K and Stuchlik A (2009). Intrahippocampal injection of dopamine D1 receptor antagonist SCH23390 interferes with locomotion and learning of active place avoidance, a spatial cognition task. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.258 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Jun 2009; Published Online: 12 Jun 2009. * Correspondence: Tomas Petrasek, ASCR, Institute of Physiology, Prague, Czechia, disworlds@seznam.cz Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Tomas Petrasek Karel Vales Ales Stuchlik Google Tomas Petrasek Karel Vales Ales Stuchlik Google Scholar Tomas Petrasek Karel Vales Ales Stuchlik PubMed Tomas Petrasek Karel Vales Ales Stuchlik Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.