Abstract
Intrahepatic cholestasis of pregnancy (ICP) is a rare disease occurring mainly during the last trimester of pregnancy. Pruritus, often accompanied by excoriation of the skin but without other skin lesions, and elevated concentrations of bile acids are characteristic for this disorder. We present a 30-year-old woman with pruritus, elevated bile acids, ASAT and ALAT in the 22nd week of pregnancy. Treatment with ursodeoxycholic acid resulted in complete disappearance of the pruritus and normalisation of the bile acids, ASAT and ALAT. A healthy child was born at term. In the differential diagnosis of liver function abnormalities during pregnancy, ICP should be included. ICP responds very well to treatment with ursodeoxycholic acid, with no detrimental effects for mother and child.
Highlights
Intrahepatic cholestasis of pregnancy relief of signs and symptoms within two to three weeks after delivery [1,2]
Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by pruritus, elevated serum aminotransferases and bile acid levels with onset in the second or third trimester of pregnancy, and spontaneous
The incidence of ICP was highest in Bolivia and Chile several decades ago, among the Araucanos Indians of Chile (27.6%) and the Aimara Indians of Bolivia (13.8%) [5,6,7,8], but has considerably decreased in these countries more recently to less than 2% of all births today
Summary
Berichte und Arbeiten aus der geburtshilflich-gynaekologischen Klinik zu Giessen 1881-1882. 4. Germain AM, Carvajal JA, Glasinovic JC, Kato CS, Williamson C: Intrahepatic cholestasis of pregnancy: an intriguing pregnancyspecific disorder. 5. Reyes H, Gonzalez MC, Ribalta J, Aburto H, Matus C, Schramm G, Katz R, Medina E: Prevalence of intrahepatic cholestasis of pregnancy in Chile. 6. Reyes H, Taboada G, Ribalta J: Prevalence of intrahepatic cholestasis of pregnancy in La Paz, Bolivia.
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