Abstract
Prolonged intoxication with 1000 ppm of 4,4′-diaminodiphenylmethane (DDPM) led to hyperplasia of bile ducts and proliferation of oval cells. Hyperplastic areas gradually regressed and were replaced by fibrous tissue after cessation of DDPM administration. Elevation of γ -glutamic transpeptidase and alkaline phosphatase in serum accompanied the proliferation of bile ductular cells.
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