Abstract
Background and study aims: To determine long-term outcome after treatment with an intra-gastric balloon for 6months, with no structured weight maintenance program offered after balloon removal. Patients and methods: 100 consecutive overweight/obese individuals (mean body mass index [BMI] 35.0±5.6kg/ m2) were prospectively fol-lowed after endoscopic implantation of a saline filled intragastric balloon; 97 completed final -follow-up at a mean of 4.8±1.6years. Success-ful intragastric balloon therapy was defined as weight loss at 6 months of ≥ 10% of weight at -baseline, that remained ≥ 10% until 2.5years, with-out bariatric surgery. All analyses followed intention-to-treat principles. Results: At 6months, mean weight loss was 12.6±8.3kg, 63 individuals had ≥ 10% baseline weight loss; no severe morbidity was detected. During the first and second years following intragastric balloon removal, mean body mass in-creased by 4.2±6.8 and 2.3±6.0kg, respectively (P
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