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Abstract
Intraflagellar transport (IFT) is essential for cilium and flagellar assembly. This movement is accomplished by two IFT complexes: A and B. IFT88, intraflagellar protein 88, is a core element of IFT complex B. This protein has been linked to migration, to olfactory function, spindle formation and to mitosis. Recently, IFT88 was identified as a TCTEX1D4 interacting protein in human testis, suggesting a role in male reproduction. To broaden the knowledge on IFT88 function, particularly in testis and spermatozoa, an in silico analysis of IFT88 and IFT88 interactome was undertaken. IFT88 appears to be prone to protein-protein interactions, involved in spermatogenesis and since it interacts with key proteins related to male fertility, it may have a role in reproduction.
Highlights
Intraflagellar transport (IFT) was described for the first time, in Chlamydomonas reinhardtii flagella, twenty years ago [1]
A bioinformatic analysis of IFT88 was performed for the first time
IFT88 sequence and interactome in silico analysis were performed with the goal of identifying biological meaningful interactions in male reproductive functions
Summary
Intraflagellar transport (IFT) was described for the first time, in Chlamydomonas reinhardtii flagella, twenty years ago [1]. It is characterized by the bi-directional movement of cargo along the flagellum or cilium and is independent from the flagellar betting and essential for cilium and flagellar assembly [2] [3]. There are three essential components for the intraflagellar transport: 1) the microtubules provides the physical support for the movement; 2) the molecular motors, kinesin and dynein power the movement and 3) the IFT complexes mediate interactions between molecular motors and cellular cargos [4]. How to cite this paper: Freitas, M.J. and Fardilha, M.
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