Abstract
The term, “cervical intraepithelial neoplasia (CIN)”, has been used to describe the continuum of squamous cell carcinoma initiation and progression. The CIN system, replacing the dysplasia system, highlights the neoplastic potential of cervical precancerous lesions. However, the term, carcinoma in situ, is kept in surgical pathology. Dysplasia is only used in describing cancer-associated morphological changes. Squamous intraepithelial lesions (SIL) are more commonly applied in cytopathology. Cervical glandular intraepithelial neoplasia (CGIN) refers to the various degrees of dysplasia in cervical glandular lesions. Most pathologists use a two-tier system to divide CGIN into low-grade and highgrade, following the TBS classification. Vulvar intraepithelial neoplasia (VIN) is also referred to as squamous cell dysplasia of the vulva. The lesion can involve skin or mucosa or both simultaneously. The histopathological diagnostic criteria of VIN are analogous to those of CIN. Vaginal intraepithelial neoplasia (VaIN) is also referred to as vaginal dysplasia and vaginal carcinoma in situ. VaIN can be primary in the vagina or secondary from CIN. The histopathological alterations of VIN and VaIN are similar to those of CIN.
Published Version
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