Intraepithelial colorectal lesions in women with cervical infection with human
 papillomavirus.

Abstract

Human papillomavirus (HPV)-induced cervical cancer and colorectal cancer are closely related. Women with cervical HPV infection have more than 3 times the high risk of anal infection. Some studies indicate a persistent relationship between colorectal cancer caused by HPV infection and a similar genotype of cervical cancer. In our research, using the method of liquid cytology, a comparison of colorectal HPV lesion in patients with dysplasia of the cervix in history and a control group without pathology of the cervix was carried out. The cytological study was performed using the method of liquid cytology BDShurePath using the automated scanning system BDFocalPoint. Detection of HPV genotypes of high oncogenic risk (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68) was carried out by hybrid capture (HPVdigene-test hybrid capture ll).The results of our studies showed that 24% of patients at high risk in the cytological examination of scrapings from the rectum had an intraepithelial lesion of the rectal epithelium, most likely associated with HPV infection. In the control group, these changes were not observed. The results show that HPV-associated pathology of the cervix is a risk factor for intraepithelial damage to the rectum. Such patients are in a group at high risk of developing colorectal cancer and should undergo a regular appropriate examination.