Intraductal papillary mucinous tumor of the pancreas and multiple adenomas of the colon

Abstract

Intraductal papillary mucinous tumor (IPMT) of the pancreas is an extremely rare entity. This type of neoplasm was first described by Ohashi et al. 1 Ohashi K Murakami Y Takekoshi T Ohta H Ohhashi I Four cases of mucus producing cancer of the pancreas on specific findings of the papilla of Vater. Prog Dig Endosc. 1982; 20: 348-351 Google Scholar in 1982 as a diffuse dilatation of the main pancreatic duct with filling defects on pancreatography and extrusion of mucin from the duodenal papilla. IPMTs exhibit various grades of dysplasia and can progress to frank carcinoma. However, the prognosis for patients is favorable if the tumor is resected. 2 Loftus EV Olivares-Pazkzad BA Batts KP Adkins MC Stephens DH Sarr MG et al. Intraductal papillary-mucinous tumors of the pancreas: clinicopathologic features, outcome, and nomenclature. Gastroenterology. 1996; 110: 1909-1918 Abstract Full Text Full Text PDF PubMed Scopus (381) Google Scholar There are few cases reported of IPMT associated with other premalignant conditions. In cited cases, the association has been with colorectal adenoma and adenocarcinoma. The K-ras mutation may be a genetic link between IPMT and colorectal adenomas that progress to frank adenocarcinoma. 3 Sugiyama M Atomi Y Hachiya J Intraductal papillary tumors of the pancreas: evaluation with magnetic resonance cholangiopancreatography. Am J Gastroenterol. 1998; 93: 156-159 Crossref PubMed Scopus (100) Google Scholar This report describes a patient with IPMT and multiple adenomas of the colon.