Intradermal vs Intramuscular Hepatitis B Vaccinations-Reply

Abstract

In Reply.— We applaud the well-designed study by Wistrom et al that demonstrates that low-dose ID inoculation of adults with three 2-μg doses of a recombinant hepatitis B vaccine (Recombivax-HB, Merck Sharp & Dohme) results in lower seroconversion rates and reduced levels of antibody to HBsAg compared with three 10-μg IM injections of the same product. These results are not unexpected. There is a positive correlation between dose and immune response regardless of the type of product used. 1 In our ID study we were able to use the more immunogenic plasma-derived Hepta