Abstract
Bone marrow transplantation (BMT) is used to treat hematological disorders, autoimmune diseases (ADs) and lymphoid cancers. Intra bone marrow-BMT (IBM-BMT) has been proven to be a powerful strategy for allogeneic BMT due to the rapid hematopoietic recovery and the complete restoration of T cell functions. IBM-BMT not only replaces hematopoietic stem cells (HSCs) but also mesenchymal stromal cells (MSCs). MSCs are multi-potent stem cells that can be isolated from bone marrow (BM), umbilical cord blood (UCB), and adipose tissue. MSCs play an important role in the support of hematopoiesis, and modify and influence the innate and adaptive immune systems. MSCs also differentiate into mesodermal, endodermal and ectodermal lineage cells to repair tissues. This review aims to summarize the functions of BM-derived-MSCs, and the treatment of intractable diseases such as rheumatoid arthritis (RA) and malignant tumors with IBM-BMT.
Highlights
This review aims to summarize the functions of bone marrow (BM)-derived-Mesenchymal stromal cells (MSCs), and the treatment of intractable diseases such as rheumatoid arthritis (RA) and malignant tumors with IBM-Bone marrow transplantation (BMT)
Mesenchymal stromal cells (MSCs) are multi-potent progenitor cells mainly isolated from bone marrow (BM) (Campagnoli et al, 2001), adipose tissue (Zuk et al, 2001), and the umbilical cord (UC) (Erices et al, 2000)
We focus on rheumatoid arthritis (RA) and malignant tumors treated with Intra bone marrow-BMT (IBM-BMT)
Summary
Reviewed by: Hong Zhang, Harvard Medical School, USA Simone Pacini, University of Pisa, Italy. Bone marrow transplantation (BMT) is used to treat hematological disorders, autoimmune diseases (ADs) and lymphoid cancers. Intra bone marrow-BMT (IBM-BMT) has been proven to be a powerful strategy for allogeneic BMT due to the rapid hematopoietic recovery and the complete restoration of T cell functions. IBM-BMT replaces hematopoietic stem cells (HSCs) and mesenchymal stromal cells (MSCs). MSCs are multi-potent stem cells that can be isolated from bone marrow (BM), umbilical cord blood (UCB), and adipose tissue. MSCs play an important role in the support of hematopoiesis, and modify and influence the innate and adaptive immune systems. MSCs differentiate into mesodermal, endodermal and ectodermal lineage cells to repair tissues. This review aims to summarize the functions of BM-derived-MSCs, and the treatment of intractable diseases such as rheumatoid arthritis (RA) and malignant tumors with IBM-BMT
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