Intracranial Stenting for Acute Ischemic Stroke

Abstract

Stroke is the third major cause of death in the US. In the past decade there has been an exponential growth in modalities to treat acute stroke with acute recanalization therapies, including intravenous thrombolysis, intra-arterial chemical thrombolysis and mechanical thrombectomy, thromboaspiration, or angioplasty. While these new modalities of therapy have been promising, there remains a very real limitation to the overall rate of successful recanalization for current standard interventions. As a result, extrapolation from the cardiac literature has lead to early efforts using primary intracranial stenting to achieve safe recanalization. A major advantage of intracranial stenting is immediate flow restoration, as time to recanalization has repeatedly been shown to be a strong predictor of outcome in stroke. We will provide a cursory review each of the major established methods of acute stroke recanalization therapy, followed by a detailed review of intracranial stenting for acute stroke recanalization.