Intracranial collateral pathways assessed by contrast-enhanced three-dimensional transcranial color-coded sonography

Abstract

Individual parameter settings of the duplex machine and limited insonation angles may influence the visualization of small intracranial vessels in 2-D transcranial color-coded sonography. The aim of our study was the morphologic assessment of intracranial collateral pathways (first auditory area celiac artery, A 1CA; anterior communicating artery, AComA; first parental generation celiac artery P 1CA; posterior communicating artery, PComA) using 3-D transcranial color-coded duplex sonography (3-D TCCS) and digital subtraction angiography (DSA). A total of 41 patients with large vessel disease and 30 patients who had suffered subarachnoidal hemorrhage (mean age 52 ± 15 years) were involved. In all patients, angiography was performed within 10 days following 3-D sonography. The patients were investigated with a color-coded duplex system using the power mode. Contrast enhancement was achieved by continuous infusion of a galactose-based echo-enhancer using a perfusor pump. The 3-D system consists of an electromagnet that induces a low-intensity magnetic field near the head of the patient. A magnetic position sensor is attached to the ultrasound (US) probe and transmits the spatial orientation to a personal computer, which also receives the corresponding 2-D images from the video port of the duplex machine. Angiography revealed a “complete” circle of Willis in one third of the patients and, in the remaining patients at least one vessel was hypoplastic or absent. Sufficient temporal bone windows allowed the sonographic investigation of 466 (94%) of 497 expected arterial segments. The comparison of both techniques resulted in a weighted kappa value of 0.56 for the A 1CA and 0.63 for the AComA. In the posterior circulation kappa values of 0.56 for the P 1CA and 0.43 for the PComA were calculated. In 50 vessels (10%), 3-D sonography misdiagnosed the diameter of a collateral vessel as normal and angiography revealed hypoplasia or aplasia of this vessel. The main advantage of 3-D TCCS is that it enables the investigator to reconstruct virtually any arbitrary view angle. Compared with angiography or magnetic resonance (MR) angiography, 3-D sonography can be performed easily in critically ill patients on stroke units or intensive care units. The noninvasive assessment of the circle of Willis may be useful in patients who undergo carotid surgery without angiography. Combined with hemodynamic information, contrast-enhanced 3-D TCCS might increase the diagnostic impact of transcranial US. (E-mail: tiemo.wessels@neuro.med.uni-giessen.de)