Abstract
STROKE is the third leading cause of death and the leading cause of adult disability in North America, Europe, and Asia ( 1 Taylor TN Davis PH Torner JC et al. Lifetime cost of stroke in the United States. Stroke. 1996; 27: 1459-1466 Crossref PubMed Scopus (677) Google Scholar , 2 Heart Disease and Stroke Statistics—2004 Update. American Heart Association, Dallas2004 Google Scholar ). Intracranial cerebral atherosclerosis accounts for approximately 8 to 10% of all ischemic strokes with a higher reported incidence in the Asian, African, and Hispanic descent populations ( 3 Caplan LR Gorelick PB Hier DB Race, sex and occlusive cerebrovascular disease: A review. Stroke. 1986; 17: 648-655 Crossref PubMed Scopus (480) Google Scholar , 4 Craig DR Meguro K Watridge C et al. Intracranial internal carotid artery stenosis. Stroke. 1982; 13: 825-828 Crossref PubMed Scopus (167) Google Scholar , 5 Wityk RJ Lehman D Klag M et al. Race and sex differences in the distribution of cerebral atherosclerosis. Stroke. 1996; 27: 1974-1980 Crossref PubMed Scopus (444) Google Scholar ). Risk factors include insulin-dependent diabetes mellitus, hypercholesterolemia, hypertension, and cigarette smoking ( 6 Ingall TJ Homer D Baker Jr, HL et al. Predictors of intracranial carotid artery atherosclerosis. Duration of cigarette smoking and hypertension are more powerful than serum lipid levels. Arch Neurol. 1991; 48: 687-691 Crossref PubMed Scopus (84) Google Scholar , 7 Inzitari D Hachinski VC Taylor DW Barnett HJ Racial differences in the anterior circulation in cerebrovascular disease. How much can be explained by risk factors? Arch Neurol. 1990; 47: 1080-1084 Google Scholar , 8 Fisher CM Cerebral arterial occlusion–remarks on pathology, pathophysiology, and diagnosis. Clin Neurosurg. 1963; 9: 88-105 PubMed Google Scholar ). In the United States, it is estimated that 40,000 to 60,000 new strokes per year are due to intracranial cerebral atherosclerosis.
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