Intracoronary ultrasound during recanalization of chronic coronary occlusions: Relation to restenosis and reocclusion after balloon angioplasty or stent implantation

Abstract

Chronic coronary occlusions carry a high recurrence rate, and coronary stenting evolves as a preferred therapy of these complex lesions. Insight into the morphology of the occluded segment by intracoronary ultrasound may provide information which may help to improve the interventional strategy and the long-term outcome. After successful recanalization of chronic coronary occlusions (4 weeks to 33 months; median 3.2 months) in 59 patients, 29 patients were treated by balloon angioplasty alone, and 30 patients received one or more coronary stents because of complicated dissections or a high-grade residual stenosis after balloon dilatation. Intracoronary ultrasound was used to assess the lesion morphology and to quantify the angioplasty result. The luminal area, the total vessel area and the extent of the plaque burden were measured proximal and distal to the occlusion and at the narrowest site within the occlusion or the coronary stents, and the elastic recoil was calculated. Plaques in chronic occlusions were predominantly hypodense, and 44% were characterized by a multilayered plaque appearance. The elastic recoil was higher in multilayered plaques than in other plaques (46 +/- 19% vs. 34 +/- 15%; p < 0.05). Based on the quantitative ultrasound measurement after the initial balloon dilatation, it appeared that the initial balloon was undersized in 54%. The lumen area in patients with balloon angioplasty alone was increased from 4.02 +/- 1.34 mm2 to 5.49 +/- 1.47 mm2 and in the stented patients from 3.58 +/- 1.04 mm2 to 7.10 +/- 1.92 mm2. The recurrence rate in patients with balloon angioplasty was 48% with 24% reocclusions. Patients with recurrence had a slightly lower lesion area (3.97 +/- 1.41 mm2 vs. 4.71 +/- 1.44 mm2; n.s.) and minimum diameter (1.82 +/- 0.31 mm vs. 2.14 +/- 0.40 mm; p < 0.05) after dilatation. In stented patients the recurrence rate was 27% with two early stent thrombosis (6.7%) and no late reocclusion. In patients with recurrence the achieved stent area was significantly smaller than in those without restenosis (5.71 +/- 0.90 mm2 vs. 7.59 +/- 1.96 mm2; p < 0.01), and the degree of vascular remodelling at the site of the occlusion was less pronounced. Intracoronary ultrasound showed sonographic plaque characteristics in chronic occlusions which responded poorly to balloon dilatation alone. Stent implantation improved considerably the luminal area gain and could reduce the long-term outcome. To further improve the recurrence rate in stents, an optimized stent expansion should be achieved, and intracoronary ultrasound could provide an ideal tool for this purpose.