Abstract
Fibers observed within the cisternae of endoplasmic reticulum of liver cells of Rana pipiens are described. Fibers were observed only in animals subjected to starvation, but the frequency of fiber occurrence was found to vary widely from animal to animal and from cell to cell within the same animal. It is, therefore, suggested that starvation is important in, but not solely responsible for, the process of fiber formation. Some characteristic morphological changes observed in fiber-containing cells are described, and a tentative theory outlining a possible sequence of steps involved in fiber formation is presented.
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