Abstract
All of the following statements regarding intracholecystic papillary-tubular neoplasm of the gallbladder are true EXCEPT which of the following?a.Intracholecystic papillary-tubular neoplasms may form radiographically detectable masses.b.Intracholecystic papillary-tubular neoplasms show varying degree of dysplastic changes.c.Intracholecystic papillary-tubular neoplasms are never associated with invasive carcinomas.d.Intracholecystic papillary-tubular neoplasms are usually identified in adults. Answer: c. Intracholecystic papillary-tubular neoplasms are never associated with invasive carcinomas. Intracholecystic papillary-tubular neoplasms (ICPNs) of the gallbladder are polypoid neoplasms. The neoplasms display a spectrum of dysplastic changes, ranging from low-grade to high-grade dysplasia.1Adsay V. Jang K.T. Roa J.C. et al.Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.Am J Surg Pathol. 2012; 36: 1279-1301Crossref PubMed Scopus (128) Google Scholar About half the cases of ICPNs of the gallbladder are associated with invasive carcinoma.1Adsay V. Jang K.T. Roa J.C. et al.Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.Am J Surg Pathol. 2012; 36: 1279-1301Crossref PubMed Scopus (128) Google Scholar, 2Argon A. Barbet F.Y. Nart D. The relationship between intracholecystic papillary-tubular neoplasms and invasive carcinoma of the gallbladder.Int J Surg Pathol. 2016; 24: 504-511Crossref PubMed Scopus (14) Google Scholar Intracholecystic papillary-tubular neoplasms without invasion have a very good prognosis.1Adsay V. Jang K.T. Roa J.C. et al.Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.Am J Surg Pathol. 2012; 36: 1279-1301Crossref PubMed Scopus (128) Google Scholar Intracholecystic papillary-tubular neoplasms even with invasion have a significantly better prognosis than conventional pancreaticobiliary-type gallbladder carcinoma.1Adsay V. Jang K.T. Roa J.C. et al.Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.Am J Surg Pathol. 2012; 36: 1279-1301Crossref PubMed Scopus (128) Google Scholar
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