Abstract
Orexins are important regulators of sleep–wakefulness (S–W). Rats were intracerebroventricularly (ICV)22ICV: Intracerebroventricular. administered selective orexin-2 receptor antagonist, TCS-OX2-2933TCS-OX2-29: (2S)-1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4pyridinylmethyl) amino]-1-butanone hydrochloride.. There was decreased wakefulness due to a decrease in the average wake episode duration and an increased REM sleep44REM: Rapid Eye Movement. due to an increase in the number of REM episodes, indicating an inhibitory role of the central orexin-2 receptors on REM sleep generation.
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