Abstract
To clarify the involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks, we examined the central effect of GLP-1 antagonist, exendin (5–39) on food intake. Intracerebroventricular co-injection of exendin (5–39) with GLP-1 attenuated the anorexigenic effect of GLP-1 in layer-type chicks. Furthermore, exendin (5–39) enhanced food intake of layer-type chicks under ad libitum feeding. However, this effect was not observed in broiler chicks. Therefore, endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks.
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