Abstract
We examined the expression of Na+/myo-inositol cotransporter (SMIT) in the rat brain after intrastriatal hemorrhage. The expression of SMIT messenger RNA (mRNA) increased around hematoma 3 days after hemorrhage and it returned to control level as hematoma was absorbed. The expression of SMIT mRNA also increased at ipsilateral substantia nigra without blood–brain barrier disruption 7 days after hemorrhage and remained high until 42 days after hemorrhage. Immunohistochemistry revealed that macrophages around hematoma and microglias at ipsilateral substantia nigra were SMIT-positive. These results suggest that the expression of SMIT must be regulated not only by osmolality but also by unknown factors.
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