Intracerebral hemorrhage in a case of antiphospholipid antibody syndrome

Abstract

BACKGROUND AND PURPOSE: The patients with lupus anticoagulants may have an increased risk for the development of ischemic brain lesions and subdural hematoma in the presence of other known risk factors. There are lots of reports related to antiphospholipid syndrome with subdural hematoma, but intra-axial bleeding is a rare complication. CASE DESCRIPTION: We report a 37-year-old man with ptosis, central typed facial palsy, hemiparesis on the right side and motor aphasia. A CT scan and MRI showed a large cerebral hematoma located in the left fronto-parietal region and other foci of hemorrhage on the right hemisphere. Only persistently abnormal finding in laboratory studies was positive for antiphospholipid antibodies. Based on above findings we concluded that anti-phospholipid antibodies have resulted in intracerebral hemorrhage. CONCLUSION: In the present case, we report and point that hemorrhagic complication in young patients with antiphospholipid antibody syndrome associated with fragility of the vessels and/or platelet dysfunction is another and rare cause of intracerebral bleeding.