Abstract
Inositol hexakisphosphate (IP 6) was pressure-injected into the somata of the identified neurons (R9-R12) in the abdominal ganglion of Aplysia. Intracellular injection of IP 6 into a neuron voltage-clamped at −45 mV reproducibly induced a biphasic membrane current consisting of an inward current ( I i(IP 6)) followed by a slow outward current ( I o(IP 6)). Conductance is increased at the peaks of these currents. The extrapolated reversal potential of I i(IP 6) was −34 mV, whereas I o(IP 6) was increased by depolarization and decreased by hyperpolarization up to −75 mV, where it disappeared. Ion substitution and pharmacological experiments suggest that microinjection of IP 6 into the Aplysia neurons activates two or more separate types of ion channels.
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