Abstract
Artificial protein-RNA hybrid ribozymes with an unwinding activity were created. Since the novel hybrid ribozymes can attack any site within mRNA, libraries can be made of the hybrid ribozymes with randomized binding arms and thus be introduced into cells. This represents a new paradigm of powerful ribozyme technology that can enjoy many unique and exciting uses for various purposes in the post-genome project era, including applications for discovery of novel functional genes associated with specific important phenotypes and targeted elimination of expression of disease-causing genes in vivo in gene therapy approaches.
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