Abstract
Tumor progression is a complex process consisting of several steps characterized by alterations in cellular behavior and morphology. These steps include uncontrolled cell division and proliferation, invasiveness and metastatic ability. Throughout these phases, cancer cells encounter a changing environment and a variety of metabolic stress. To meet their needs for energy while they proliferate and survive in their new environment, tumor cells need to continuously fine-tune their metabolism. The connection between intracellular transport and metabolic reprogramming during cancer progression is emerging as a central process of cellular adaptation to these changes. The trafficking of proteolytic enzymes, surface receptors, but also the regulation of downstream pathways, are all central to cancer progression. In this review, we summarize different hallmarks of cancer with a special focus on the role of intracellular trafficking in cell proliferation, epithelial to mesenchymal transition as well as invasion. We will further emphasize how intracellular trafficking contributes to the regulation of energy consumption and metabolism during these steps of cancer progression.
Highlights
During cancer progression, tumor cells go through different stages, which are defined as hallmarks of cancer
When epithelial cells transition to cancer cells, they lose their epithelial phenotype and acquire a mesenchymal phenotype during a process called epithelial to mesenchymal transition (EMT) (Sciacovelli and Frezza, 2017)
It is widely recognized that different metabolic needs are encountered during cancer progression
Summary
Reviewed by: Chad Williamson, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), United States Antonino Colanzi, Institute of Biochemistry and Cell Biology, National Research Council (CNR), Italy. Tumor progression is a complex process consisting of several steps characterized by alterations in cellular behavior and morphology. These steps include uncontrolled cell division and proliferation, invasiveness and metastatic ability. Throughout these phases, cancer cells encounter a changing environment and a variety of metabolic stress. We will further emphasize how intracellular trafficking contributes to the regulation of energy consumption and metabolism during these steps of cancer progression
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