Abstract

To determine whether the arrangement of microfilaments in retinal vascular endothelium is altered in early diabetes. F-actin and nuclei of retinal vascular endothelial cells of normal and diabetic (28 weeks postinduction) rats were examined using confocal microscopy. An increase in the incidence of aberrant F-actin bundle arrangement in the diabetic retinal arteriole was observed, but there was no disruption of peripheral border F-actin. The diameter of superficial capillaries was increased in diabetic rats. These changes may be related to the endothelial dysfunction demonstrated in a previous pharmacological study.

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