Abstract
Experimental data are presented on the intracellular localization in rat liver of three enzymes which are involved in the biosynthesis of phosphatidylethanolamine and diphosphatidylglycerol. These enzymes are phosphatidylserine decarboxylase, CDP-diglyceride-l-alpha-glycerophosphate phosphatidyl transferase, and phosphatidylethanolamine-l-serine phosphatidyl transferase. It was found that the first two enzymes are primarily mitochondrial while the latter enzyme is primarily microsomal. The intracellular sites for the biosynthesis of phosphatidylcholine, phosphatidylethanolamine, and diphosphatidylglycerol are discussed, and the implications of their sites of biosynthesis on the assembly processes involved in the biogenesis of mitochondria are considered.
Highlights
Experimentaldata are presented on the intracellular localizationin rat liver of three enzymes which are involved in the biosynthesis of phosphatidylethanolamine and diphosphatidylglycerol
We present some new experimental data on the intracellular localization in rat liver of three enzymes which catalyze essential steps in the formation of phosphatidylethanolamine and of diphosphatidylglycerol
Fresh rat liver was separated into the following five fractions according to the procedure of Wilgram and Kennedy (3): 7) nuclei and debris, 2) mitochondria, 3) intermediate fraction, 4) microsomes, and 5) soluble supernatant fraction
Summary
Experimentaldata are presented on the intracellular localizationin rat liver of three enzymes which are involved in the biosynthesis of phosphatidylethanolamine and diphosphatidylglycerol. These enzymes are phosphatidylserine decarboxylase, CDP-diglyceride-L-a-glycerophosphatephosphatidyl transferase, and phosphatidylethanolamine-L-serinephosphatidyl transferase. It was found that the first two enzymes are primarily mitochondrial while the latter enzyme is primarily microsomal. The intracellular sites for the biosynthesis of phosphatidylcholine, phosphatidylethanolamine, and diphosphatidyiglycerol are discussed, and the implications of their sites of biosynthesis on the assembly processes involved in the biogenesis of mitochondria are considered
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