Abstract
Despite remarkable progresses in nucleic acid-targeted tumor therapy, intracellular RNA and nuclear DNA-dual-targeted cancer treatments via a single nano-delivery system have been little investigated. Herein, cis-platinum pro-drugs (DSP) and cytotoxic protein ribonuclease A (RNase A) dual-therapeutic agents-loaded large-pore mesoporous silica-coated β-NaYF4:20%Yb,2%Er@β-NaGdF4 upconversion nanoplatforms (UCSPtR) were prepared for chemo-protein combination therapy. The obtained upconversion nanoplatforms can not only transport cytotoxic protein molecules and DSP into tumor cells to induce intracellular RNA degradation-mediated and nuclear DNA-targeted killings of cancer cells, but also achieve upconversion luminescence (UCL) and magnetic resonance (MR) dual-mode bioimaging. We believe this RNA and DNA-dual-targeted nanosystem will provide more enlightenments for tumor therapy.
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