Abstract
~~ protein substrates that are susceptible to that machinery to a greater or lesser extent. The study of bulk proteolysis, usually determined as the appearance of acid-soluble low-M, products derived from a prelabelled protein pool, yields information primarily on the cellular locations and machinery that is responsible for the late events in cellular proteolysis. By contrast, the measurement of the half-life of native individual proteins allows the derivation of the rate but yields little about the route of degradation. However, information on absolute, relative and changing rates of degradation of individual proteins may be correlated with structural properties, permitting some analysis of the features of the substrate that might dispose
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