Abstract
Cells constantly exchange material and information with their environment through a variety of trafficking mechanisms. Membrane trafficking encompasses a broad range of biological processes, all of which are characterized by the local deformation and movement of the plasma membrane. These movements are orchestrated by a complex protein machinery and cytoskeletal rearrangements. While different membrane trafficking pathways use different sets of proteins, mathematical and computational models have been used with great success to identify some of the governing physical principles. Here, we review the different theoretical and computational models of local movements in cells and the insights obtained from them. We will also highlight the challenges in the field and discuss future directions.
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