Abstract
In this study, we describe the design of new ratiometric fluorescent nanosensors, whosearchitecture is based on a gold core surrounded by a poly(vinyl alcohol)–polyacetal shell. Tothe gold core, indicator dyes and reference dyes are attached via a cysteine linker. Thisnanosensor architecture is flexible with regards to the number and types of fluorophorelinkages possible. The robust poly(vinyl alcohol)–polyacetal shell protects the fluorophoreslinked to the core from non-specific interactions with intracellular proteins. Thenanosensors developed in this way are biocompatible and can be easily incorporatedinto mammalian cells without the use of transfection agents. Here, we show theapplication of these nanosensors for intracellular pH and sodium ion measurements.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
