Abstract
1. 1. The enzyme, carbonic anhydrase (carbonate hydro-lyase, EC 4.2.1.1), has been studied in the mucosal cells of the avian ( Gallus domesticus) shell gland and has been found to be a soluble constituent of these cells. 2. 2. Mitochondrial and microsomal fractions showed very low and non-fluctuating levels of carbonic anhydrase activity. These findings support a non-membrane-attached, intracellular role for the enzyme. 3. 3. Intramuscular injections of the specific inhibitor, acetazolamide, were correlated with decreases of enzymatic activity in the mucosal cells and with decreases in egg shell weight. These results have been interpreted to indicate an intimate association of the enzyme in the shell gland mucosal cells with CaCO 3 deposition. 4. 4. The fine structure of the shell gland mucosa in normal and acetazolamide-treated laying hens did not reveal ultrastructural changes in conjunction with carbonic anhydrase inhibition. 5. 5. A model of the mode of action of carbonic anhydrase in the shell gland mucosa is discussed .
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