Abstract
Abstract Here, we report that the gold nanoparticle–DNA aptamer (AuNP–Apt) conjugate-based system can efficiently deliver recombinant proteins into mammalian cells in a manner independent of their size, isoelectric point, and cellular localization. Additionally, AuNP–Apt system-assisted protein delivery can be effective on primary and stem cells, indicating that its use is not limited to fast-dividing cells. We further show that the intravenously administered AuNP–Apt system can deliver proteins into rat organs. Our findings show that this system can serve as a simple, efficient, and versatile platform for the delivery of recombinant proteins into mammalian living systems.
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