Abstract
Abstract A 1:2 inclusion complex composed of 5-[4-(tetraglutaminylglutaramido)phenyl]-10,15,20-tris(4-sulfonatophenyl)porphyrin and per-O-methylated β-cyclodextrin interacted electrostatically with a dodecaarginine in aqueous solution. Such a ternary complex dispersed in a serum-containing culture medium was efficiently taken up by HeLa cells. This cellular uptake was achieved owing to the interaction between the tetraglutamate chain of the porphyrin and dodecaarginine carrier peptide.
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