Abstract
The early gingival lesion is characterised by the rapid loss of collagen fibres within the infiltrated area of connective tissue. In the Beagle dog this in accompanied by morphological changes in fibroblasts around the advancing edge of the inflammatory cell infiltrate. The plasma membranes are thrown into complex folds and the cytoplasm contains numerous apparently intracellular collagen fibrils within membrane bound vacuoles. Similar vacuoles are occasionally present within macrophages. It is suggested that following initial attack by neutral collagenase, further breakdown of collagen in the early gingival lesion may occur intracellularly.
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