Intracavitary hyperthermic chemoperfusion in patients with far-advanced gastric cancer or rectal cancer

Abstract

Background Local recurrence after surgery for patients with advanced gastric cancer and rectal cancer is often fatal. In an attempt to prevent local recurrences, we carried out intracavitary hyperthermic chemoperfusion (IHCP) combined with surgery. Methods 60 patients with advanced gastric cancer and 27 patients with advanced rectal cancer were treated with IHCP plus surgery and, 52 and 35 patients with advanced gastric and rectal cancer, respectively, were treated by surgery alone. Results In case of rectal cancer, the incidence of local recurrence in the IHCP group is 3/27 patients (11.1%) and that in the control group is 13/35 patients (37.1%), thus differences between the groups are significant at p=0.043. With regard to gastric cancer, 13/60 patients (21.7%) in the IHCP group had a peritoneal recurrence and in the control group 40/52 patients (76.9%) had a recurrence; the statistical difference between the groups being significant (p=6.43 × 10−9). Conclusions IHCP treatment can diminish the incidence of local recurrence after surgical treatment for patients with advanced gastric or rectal cancer.