Intra-Cardiac Flow from Geometry Prescribed Computational Fluid Dynamics: Comparison with Ultrasound Vector Flow Imaging.

Abstract

This paper investigates the accuracy of blood flow velocities simulated from a geometry prescribed computational fluid dynamics (CFD) pipeline by applying it to a dynamic heart phantom. The CFD flow patterns are compared to a direct flow measurement by ultrasound vector flow imaging (VFI). The hypothesis is that the simulated velocity magnitudes are within one standard deviation of the measured velocities. The CFD pipeline uses computed tomography angiography (CTA) images with 20 volumes per cardiac cycle as geometry input. Fluid domain movement is prescribed from volumetric image registration using the CTA image data. Inlet and outlet conditions are defined by the experimental setup. VFI is systematically measured in parallel planes, and compared to the corresponding planes in the simulated time dependent three dimensional fluid velocity field. The measured VFI and simulated CFD have similar flow patterns when compared qualitatively. A quantitative comparison of the velocity magnitude is also performed at specific regions of interest. These are evaluated at 11 non-overlapping time bins and compared by linear regression giving R2 = 0.809, SD = 0.060 m/s, intercept = -0.039 m/s, and slope = 1.09. Excluding an outlier at the inlet, the correspondence between CFD and VFI improves to: R2 = 0.823, SD = 0.048 m/s, intercept = -0.030 m/s, and slope = 1.01. The direct comparison of flow patterns shows that the proposed CFD pipeline provide realistic flow patterns in a well-controlled experimental setup. The demanded accuracy is obtained close to the inlet and outlet, but not in locations far from these.