Abstract
BackgroundTo test the hypothesis that triolein emulsion will increase vascular permeability of skeletal muscle.MethodsTriolein emulsion was infused into the superficial femoral artery in rabbits (triolein group, n = 12). As a control, saline was infused (saline group, n = 18). Pre- and post-contrast T1-weighted MR images were obtained two hours after infusion. The MR images were qualitatively and quantitatively evaluated by assessing the contrast enhancement of the ipsilateral muscles. Histologic examination was performed in all rabbits.ResultsThe ipsilateral muscles of the rabbits in the triolein group showed contrast enhancement, as opposed to in the ipsilateral muscles of the rabbits in the saline group. The contrast enhancement of the lesions was statistically significant (p < 0.001). Histologic findings showed that most examination areas of the triolein and saline groups had a normal appearance.ConclusionRabbit thigh muscle revealed significantly increased vascular permeability with triolein emulsion; this was clearly demonstrated on the postcontrast MR images.
Highlights
To test the hypothesis that triolein emulsion will increase vascular permeability of skeletal muscle
As emulsified triolein or fatty acids change the vascular permeability of the brain [1,2], the testis [3], and the orbit [4], a fat emulsion model may be useful in studies regarding methods of drug delivery
The vascular permeability of the skeletal muscles of the thigh increased with infusion of a triolein emulsion into the superficial femoral artery in the present study
Summary
To test the hypothesis that triolein emulsion will increase vascular permeability of skeletal muscle. The vascular endothelium serves as a barrier with protective properties. This barrier can, be an obstacle to drug delivery. As emulsified triolein or fatty acids change the vascular permeability of the brain [1,2], the testis [3], and the orbit [4], a fat emulsion model may be useful in studies regarding methods of drug delivery. We hypothesized that an emulsified triolein could be useful in a vascular permeability study of the skeletal muscle since significant pathologic changes did not occur in the brain
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