Abstract
Objective. To assess the blood serum IL-10 concentration in patients with intra-abdominal infections.
 Materials and methods. Clinical specimens were obtained from 56 patients, suffering intra-abdominal infections of various origin: 24 patients - with postoperative abscesses, 12 - with primary intra-abdominal abscesses, and 20 - with diffuse or local peritoneal collection at the day before surgical intervention, on 2nd-3rd day and on 5th-7th day after it.
 Results. There was no trustworthy difference established between the blood serum IL-10 concentrations in patients with different origin of intra-abdominal infections in perioperative period. The significant difference was established, while comparing concentrations of IL-10 in the blood serum in patients with intra-abdominal infections before and on the days 2-3 and 5-7 postoperatively, and in healthy persons.
 Conclusion. Concentration of the blood serum IL-10 ≥ 6.78 pg/mL in patients with different origin of intra-abdominal infections has significant prognostic significance: sensitivity (92.86%) and specificity (80.65%). Further studies, targeting a specific causative agent of nosocomial infection and the cytokine response, are needed.
Highlights
Intra–abdominal infections (IAI) are the second most common cause of infectious mortality in intensive care units [1, 2]
All patients were divided into three group: Group 1 – 24 patients with POA, Group 2 – 12 patients with primary intra–abdominal abscesses (PIAA), and Group 3 – 20 patients with diffuse or local peritoneal collection (PC) due to IAI only
IL–10 as an anti–inflammatory cytokine was investigated in serum of 56 patients with different origin of IAI before and during 7 days after surgical intervention
Summary
Intra–abdominal infections (IAI) are the second most common cause of infectious mortality in intensive care units [1, 2]. Complicated intra–abdominal infection, which extends into the peritoneal space, is associated with abscess formation and peritonitis [3]. Complicated intra–abdominal infection are an important cause of morbidity and mortality, especially poorly managed. One multi–centred observational study in 132 medical institutions worldwide during 4–month period with 4553 patients with complicated IAI has shown mortality 9.2% (416/4533) [4]. Nowadays the mechanisms of the postoperative immune dysfunction are still subject of numerous studies [5]. The inflammatory reaction based on the postoperative immune suppression predisposes for septic complications. Acquired immune dysfunction is associated with a higher mortality rate in case of septic complications [6]. The principal routine function of IL–10 appears to be to limit and terminate inflammatory responses [7]. The role of IL– 10 in clinical approaches to the diagnosis of complicated and non–complicated IAI is not fully comprehend
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