Abstract
BackgroundSurgery is the only curative treatment for intraabdominal and retroperitoneal sarcoma (IaRS). Little is known about how to treat patients with recurrence. We here report the outcome in primary and recurrent sarcoma treated at the Sarcoma Center in Aarhus, Denmark.MethodsAll patients evaluated for IaRS from June 1998 to May 2008 were enrolled and data on symptoms, signs, means of diagnosis, extent of surgery, perioperative complications, mortality and long time survival were registered. Primary and first-recurrence sarcomas were analyzed separately.ResultsSixty-five of 73 primary and 22 of 28 first-recurrence IaRS had surgery. Fifty-three (82%) and 11 (50%) patients achieved radical R0 resection. Age and radicality of surgery were independent predictors of death, while recurrence of sarcoma was not. Perioperative mortality was 2.3%. 5-year survival was 70.2% for primary and 51.8% for first-recurrent sarcomas. However, patients with radical surgery had 5-year survival of over 70% in both the primary and recurrent group.ConclusionsThe radicality of surgery is the most important prognostic factor. Patients with recurrence have an equally good prognosis as those with primary sarcoma if radicality is achieved and such surgery should not be considered only as a palliative effort.
Highlights
Surgery is the only curative treatment for intraabdominal and retroperitoneal sarcoma (IaRS)
Patients and methods From June 1998 to May 2008 all patients over 18 years of age with IaRS examined at the sarcoma center at the surgical department P, Aarhus University Hospital, were registered consecutively
Patients with primary sarcoma or any first recurrence of sarcoma were included in the statistical analysis while patients with more than one recurrence were excluded from the study
Summary
Surgery is the only curative treatment for intraabdominal and retroperitoneal sarcoma (IaRS). Soft tissue sarcomas are a heterogeneous group of malignant tumors originating from mesenchymal cells. They constitute just under 1% of all cancers [1], corresponding to only 9000 new cases annually in US, and 1500 in UK [1,2]. 20% of soft tissue sarcomas arise from intraabdominal or retroperitoneal cells [3], and the three most prevalent histopathological types are gastrointestinal stromal tumor (GIST), leiomyosarcoma, and liposarcoma [4-6]. The aim of the present prospective cohort study is to report the outcome of surgical treatment of primary as well as recurrent sarcoma in our center over the last 10 years
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