Intra-uterine growth restriction as a risk factor for hypertension in children six to 10 years old : cardiovascular topic

Agata Zamecznik,Katarzyna Niewiadomska-Jarosik,Jerzy Stanczyk,Jadwiga Justyna Moll,Agnieszk Wosiak

doi:10.5830/cvja-2014-009

Abstract

SummaryIntroductionIntra-uterine growth restriction (IUGR) is present in about 3–10% of live-born newborns and it is as high as 20–30% in developing countries. Since the 1990s, it has been known that abnormalities during foetal growth may result in cardiovascular disease, including hypertension in adulthood.MethodsThis study evaluated blood pressure parameters (using ambulatory blood pressure monitoring) in children aged six to 10 years old, born as small for gestational age (SGA), and compared them to their healthy peers born as appropriate for gestational age (AGA).ResultsIn the SGA group, an abnormal blood pressure level (prehypertension or hypertension) was present significantly more often than in the AGA group (50 vs 16%, p < 0.01). This relationship also occurred in association with the type of IUGR (asymmetric p < 0.01, symmetric p < 0.05).ConclusionIn SGA children, abnormal blood pressure values occurred more frequently than in AGA children.

Highlights

Intra-uterine growth restriction (IUGR) is present in about 3–10% of live-born newborns and it is as high as 20–30% in developing countries
The aim of this study was to compare blood pressure parameters in children born as small for gestational age (SGA) and compare them with their healthy peers born as appropriate for gestational age (AGA), and to determine the prevalence of prehypertension and hypertension in both groups, taking into consideration the type of hypotrophy and birth weight percentile (≤ 5th percentile/5–10th percentile)
An analysis was performed on the prevalence of risk factors of IUGR in children in the AGA and SGA groups, with an additional division into symmetrical and asymmetrical type

Summary

Introduction

Intra-uterine growth restriction (IUGR) is present in about 3–10% of live-born newborns and it is as high as 20–30% in developing countries. Since the 1990s, it has been known that abnormalities during foetal growth may result in cardiovascular disease, including hypertension in adulthood. Results: In the SGA group, an abnormal blood pressure level (prehypertension or hypertension) was present significantly more often than in the AGA group (50 vs 16%, p < 0.01). This relationship occurred in association with the type of IUGR (asymmetric p < 0.01, symmetric p < 0.05). Conclusion: In SGA children, abnormal blood pressure values occurred more frequently than in AGA children

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