Abstract
Intra- or Intercomplex Binding to the γ-Secretase Enzyme: A MODEL TO DIFFERENTIATE INHIBITOR CLASSES
Highlights
␥-Secretase is one of the critical enzymes required for the generation of amyloid- peptides from the -amyloid precursor protein
Because amyloid- peptides are generally accepted to play a key role in Alzheimer disease, ␥-secretase inhibition holds the promise for a disease-modifying therapy for this neurodegenerative condition
We show that the two principal classes of inhibitor described in the scientific and patent literature, aspartyl protease transition state analogue and small molecule non-transition state inhibitors, display fundamental differences in the way they interact with the enzyme
Summary
␥-Secretase is one of the critical enzymes required for the generation of amyloid- peptides from the -amyloid precursor protein. To elucidate further the inhibitory mechanism of non-transition state analogue inhibitors, we have characterized the binding sites for representative molecules of the main inhibitor classes on the ␥-secretase enzyme.
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