Abstract
Purpose: Intra-articular (IA) mineralization due to crystal deposition may contribute to OA pathology through inflammation, release of pro-catabolic factors, or altered cartilage biomechanical properties. Prior conflicting studies regarding whether chondrocalcinosis (from IA mineralization) is associated with OA structural progression were limited by the use of insensitive radiographs for visualizing IA mineralization. We studied the relation of IA mineralization on CT (a more sensitive modality) to cartilage loss on knee MRI in older adults, with particular attention to potential joint location- and tissue-specific effects of mineralization on cartilage pathology.
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